Forskningspublikationer

”En stark och tydlig koppling till forskarsamhället är oerhört viktig för vår nuvarande och kommande utveckling. Lipigon vilar stadigt på Olivecronas över 50-åriga forskningsgärning men vi får inte bli bekväma och tappa den spets vi har.”

Stefan K Nilsson,
VD/Grundare Lipigon

Lipigons huvudgrundare professor emerita Gunilla Olivecrona och Dr. Stefan K. Nilsson är aktiva lipidforskare. Nedan visas utvalda publikationer inom Lipigons forskningsfält från 2006 och framåt.

Orginalpublikationer

Fischer, A.W., Jaeckstein, M.Y., Gottschling, K., Heine, M., Sass, F., Mangels, N., Schlein, C., Worthmann, A., Bruns, O.T., Yuan, Y., Zhu, H., Chen, O., Ittrich, H., Nilsson, S.K., Stefanicka, P., Ukropec, J., Balaz, M., Dong, H.,. Sun, W., Reimer, R., Scheja, L., Heeren, J. Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation. Cell Metab. Online from Dec 22, 2020.

Kovrov, O., Kristensen, K.K., Larsson, E., Ploug, M., Olivecrona, G.. On the mechanism of angiopoietin-like protein 8 for control of lipoprotein lipase activity. J. Lipid Res. 60:783–793, 2019.

Nyrén, R., Makoveichuk, E., Malla, S., Kersten, S., Nilsson, S.K., Ericsson, M., Olivecrona, G. Lipoprotein lipase in mouse kidney: effects of nutritional status and high-fat diet. Am J Physiol Renal Physiol. 316:F558-F571, 2019.

Makoveichuk, E., Vorrsjö, E., Olivecrona, T., Olivecrona, G. TNF-α decreases lipoprotein lipase activity in 3T3-L1 adipocytes by up-regulation of angiopoietin-like protein 4. Biochim. Biophys Acta 1862:533-540, 2017.

Reimund, M., Kovrov, O., Olivecrona, G., Lookene, A. Lipoprotein lipase activity and interactions studied in human plasma by isothermal titration calorimetry. J Lipid Res. 58:279-288, 2017.

Bartelt, A., John, C., Schaltenberg, N., Berbée, J.F.P., Worthmann, A., Cherradi, M.L., Schlein, C., Piepenburg, J., Boon, M.R., Rinninger, F., Heine, M., Toedter, K., Niemeier, A., Nilsson, S.K., Fischer, M., Wijers, S.L., van Marken Lichtenbeldt, W., Scheja, L., Rensen, P.C.N., Heeren, J. Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport. Nat. Commun. 8:15010, 2017.

Nilsson, J., Ericsson, M., Motamedi Joibari, M., Anderson, F., Carlsson, L., Nilsson, S.K., Sjödin, A., Burén, J. A low-carbohydrate high-fat diet decreases lean mass and impairs cardiac function in pair-fed female C57BL/6J mice. Nutr. Metab. 13:79, 2016.

Mysling, S., Kristensen, K.K., Larsson, M., Kovrov, O., Bensadoun, A., Jørgensen, T.D.J., Olivecrona, G., Young S.G., Ploug, M. ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoproteins lipase and that unfolding is counteracted by GPIHBP1. eLIFE 5:e20958, 2016.

Caraballo, R., Larsson, M., Nilsson, S.K., Ericsson, M., Qian, W., Nguyen Tran, N.P., Kindahl, T., Svensson, R., Saar, V., Artursson, P., Olivecrona, G., Enquist, P.-A., Elofsson, M. Structure-activity relationships of small molecules lowering plasma triglycerides. Eur. J. Med. Chem.  103:191-209, 2015.

Savonen, R., Hiden, M. Hultin, M., Zechner, R., Levak-Frank, S., Olivecrona, G., Olivecrona, T. The tissue distribution of lipoprotein lipase determines where chylomicrons bind.  J Lipid Res 56:588-598, 2015.

Åvall, K., Alli, Y., Leibiger, I.B., Leibiger, B., Moede, T., Paschen, M., Dicker, A., Daré, E., Köhler, M., Ilegems, E., Abdulreda, M.H., Graham, M., Crooke, R.M., Tay, V.S.Y., Refai, E., Nilsson, S.K., Jacob, S., Selander, L., Berggren, P.-O., Juntti-Berggren, L. Apolipoprotein CIII links insulin resistance to b-cell failure in diabetes. Proc. Natl. Acad. Sci. USA, 112:E2611-E2619, 2015.

Larsson, M., Caraballo, R., Ericsson, M., Lookene, A., Enquist, P.-A., Elofsson, M., Nilsson, S.K., Olivecrona, G. Identification of a small molecule that stabilizes lipoprotein lipase in vitro and lowers triglycerides in vivo. Biochem. Biophys. Res. Commun.,. 450:1063-1069, 2014.

Catoire, M., Alex, S., Paraskevopulos, N., Mattijssen, F., Evers-van Gogh, I., Schaart, G., Jeppesen, J., Kneppers, A., Mensink, M., Voshol, P.J., Olivecrona, G., Soon Tan, N., Hesselink, M.K.C., Berbée, J.F., Rensen, P.C.N., Kalkhoven, E., Schrauwen, P., Kersten, S. Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise. Proc. Natl. Acad. Sci. USA, 111:E1043-1052, 2014.

Mendoza-Barbera, E., Julve, J., Nilsson, S.K., Lookene, A., Martín-Campos, J.M., Roig, R., Lechuga-Sancho, A.M., Sloan, J.H., Fuentes-Prior, P., Blanco-Vaca, F. Structural and functional analysis of APOA5mutations identified in patients with severe hypertriglyceridemia. J Lipid Res. 54:649-661, 2013.

Larsson, M., Vorrsjo, E., Talmud, P., Lookene, A., Olivecrona G.  Apolipoprotein C-I and C-III inhibit lipoprotein lipase activity by displacement of the enzyme from lipid droplets. J Biol Chem.288:33997-40008, 2013.

Klingenberg, R., Gerdes, N., Badeau,R.M. Giestra, A., Strodthoff , D., Ketelhuth, D.F., Lundberg, A.M., Rudling, M.,  Nilsson, S.K., Olivecrona, G.,  Zoller, S., Lohmann, C., Lüscher, T.F., Jauhiainen, M., Sparwasser T., Hansson, G.K.  Depletion of Foxp3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis. J. Clin Invest. 123:1223-1334, 2013.

Nyrén, R., Chang, C.L., Lindström, P., Barmina, A., Vorrsjö, E., Ali, Y., Juntti-Berggren, L., Bensadoun, A., Young, S.G., Olivecrona, T., Olivecrona, G. Localization of lipoprotein lipase and GPHBP1 in mouse pancreas: effects of diet and leptin deficiency. BMC Physiology. 12:14, 2012

Kroupa, O., Vorrsjö, E., Stienstra, R., Mattijssen, F., Nilsson, S.K., Sukonina, V., Kersten, S., Olivecrona, G., Olivecrona, T. Linking nutritional regulation of ANGPTL4, GPIHBP1, and LMF1 to lipoprotein lipase activity in rodent adipose tissue. BMC Physiology. 12:13, 2012

Nilsson, S.K., Anderson, F., Ericsson, M., Larsson, M., Makoveichuk, E., Lookene, A., Heeren, J., Olivecrona, G. Triacylglycerol-rich lipoproteins protect lipoprotein lipase from inactivation by ANGPTL3 and ANGPTL4. Biochim Biophys Acta. 1821:1370-1378, 2012.

Gordts, P.L.S., Bartelt, A., Nilsson, S.K., Annaert, W., Christoffersen, C., Nielsen, L.B., Heeren, J., Roebroek, A.J.M. Impaired LDL receptor-related protein 1 translocation correlates with improved dyslipidemia and atherosclerosis in apoE-deficient mice. PLos One 7:e38330, 2012.

Drager, L.F., Li, J., Shin, M.-K. Reinke, C., Aggrawal, N.R., Jun, J.C., Bevans-Fonti, S.,  Sztalryd, C., O’Byrne, S.M., Kroupa, O., Olivecrona, G., Blaner W.S., Polotsky, V.Y Intermittent hypoxia inhibits clearance of triglyceride rich lipoproteins and inactivates adipose lipoprotein lipase in a mouse model of sleep apnea.  Eur Heart J 33:783-790, 2012.

Davies, B.S.J., Beigneux, A.P., Barnes, R.H., Tu, Y., Gin, P., Weinstein, M.M., Nobumori, C., Nyrén, R., Goldberg, I., Olivecrona, G., Bensadoun, A., Young, S.G., Fong, L.G. GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries. Cell Metab 12:42-52, 2010.

Shen, Y., Lookene, A., Zhang, L., Olivecrona, G. Site-directed mutagenesis of apolipoprotein CII to probe the role of the secondary structure for activation of lipoprotein lipase. J Biol Chem 285:7484-7492, 2010.

Olivecrona, G., Ehrenborg, E., Semb, H., Makoveichuk, E., Lindberg, A., Hayden, M.R., Gin, P., Davies, B.S.J., Weinstein, M.M., Fong, L.G., Beigneux, A.P., Young, S.G., Olivecrona, T., and Hernell, O. Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia. J Lipid Res 51:1535-1545, 2010.

Nilsson, S.K., Christensen, S., Raarup, M.K., Ryan, R.O., Nielsen, M.S., Olivecrona G. Endocytosis of apolipoprotein AV by members of the low density lipoprotein receptor and the Vps10p domain receptor families. J Biol Chem 283:25920-25927, 2008.

Dorfmeister, B., Zeng, W.W., Dichlberger, A., Nilsson, S.K., Schaap, F.G., Hubacek, J.Lookene, A., Putt, W., Whittall, R., Lee, P.J., Lins. L., Delsaux, N., Nierman, M., Kuivenhoven, J.A., Kastelein, J.J., Vrablik, M., Olivecrona, G., Schneider, W.J., Heeren, J., Humphries, S.E., Talmud, P.J. Effects of Six APOA5 Variants, Identified in Patients With Severe Hypertriglyceridemia, on In Vitro Lipoprotein Lipase Activity and Receptor Binding. Arterioscler Thromb Vasc Biol.28:1866-1871, 2008.

Nilsson, S.K., Lookene, A., Beckstead, J.A., Gliemann, J., Ryan, R.O., Olivecrona, G. Apolipoprotein A-V interaction with members of the low density lipoprotein receptor gene family. Biochemistry 46:3896-3904, 2007.

Sukonina, V., Looekene, A., Olivecrona, T., Olivecrona, G. Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue. Proc Natl Acad Sci USA In press, 2006.

Bokkapitel och reviews

Olivecrona, G. Role of lipoprotein lipase in lipid metabolism. Curr Opin Lipidol 27:233-241, 2016. 

Nilsson, S.K., Heeren, J., Olivecrona G., Merkel, M. Apolipoprotein A-V; a potent triglyceride reducer.  Atherosclerosis. 219:15-21, 2011.