Pressmeddelanden

Lipigon enters agreement with HitGen to develop drugs for cardiometabolic diseases

Lipigon enters agreement with HitGen to develop drugs for cardiometabolic diseases Lipigon Pharmaceuticals AB ("Lipigon"), developer of therapeutics for lipid-related diseases, today announced that the company has entered an agreement with STAR listed (Shanghai market) company HitGen Inc. ("HitGen"). The companies will conduct joint research to identify and develop drug candidates that enhance the activity of Lipoprotein Lipase (LPL), with the aim to be used in treatment of lipid disorders and cardiovascular disease.

Lipigon and HitGen will collaborate in discovery and development of small molecules targeting LPL. HitGen is a world leading biotech company in DNA encoded library-screening, a high throughput compound screening technology, where more than 100 000 times larger libraries can be used than in traditional drug discovery. The platform thus enables faster identification of innovative drug candidates with desired characteristics to target LPL effectively and safely. The companies will work jointly in discovery and early drug development. Lipigon will be responsible for clinical development and outlicensing of the commercialization rights to drug candidates, while HitGen is eligible to receive revenue sharing from Lipigon.

"HitGen is a perfect partner for us in this program, with their cutting-edge DEL platform for screening. Their technology is well established and is now widely used by leading global pharmaceutical and biotech companies", said Dr. Stefan K Nilsson, CEO and co-founder of Lipigon. "We believe that this alliance will allow us to deliver innovative medicines for millions of people at risk for cardiometabolic diseases."

"We are delighted to enter this collaboration with Lipigon. We believe the collaboration will reinforce the role and reputation of HitGen's platform in the rapidly developing field of DNA-encoded libraries (DELs) and further demonstrates the power of our DEL platform to discover novel small molecules against a variety of targets. We will work closely with Lipigon scientists to generate new small-molecule lead compounds for their research programs to help bring transformative medicines to patients," said Dr. Jin Li, Chairman of the Board and Chief Executive Officer of HitGen. 

Press Release Umeå May 14th 2020

For further information, please contact:

Stefan K Nilsson, CEO Lipigon

Mobile +46 70-578 17 68

Mail: stefan@lipigon.se

About LPL (Lipoprotein Lipase)

LPL is an established drug target with a validated and active interest from big pharma companies. There is strong clinical, epidemiological and genetic support for targeting LPL. Deficiency of LPL is associated with an increased risk of cardiovascular disease and elevated plasma lipid levels. Lipigon was founded by world leading experts with an extensive scientific history working with LPL and therefore has a great potential to successfully develop new candidates to the target.

About Lipigon Pharmaceuticals AB

Lipigon develops novel therapeutics for patients with lipid- related disorders. The company is a spin-off from Umeå University, Sweden, based on five decades of lipid research. Our primary focus is orphan lipid disorders and in addition to the ANGPTL antisense program, Lipigon's pipeline includes a program for gene therapy in lipodystrophy, together with Combigene AB (publ). www.lipigon.se.

About HitGen Inc.

HitGen is a rapidly growing biotech company with headquarters based in Chengdu, China, and a subsidiary in the USA. HitGen has established an industry-leading platform for early-stage drug discovery research, based on DNA encoded chemical libraries (DELs). HitGen is partnering with multiple pharmaceutical and biotech companies in North America, Europe and Asia to discover and develop novel therapeutics of the future.

For more information, please call +86-28-85197385 or visit www.hitgen.com.

For media inquiries: media@hitgen.com

For investor inquiries: investors@hitgen.com

For business development: bd@hitgen.com

2021-11-24
Regulatorisk

Lipigon Pharmaceuticals AB ("Lipigon") publicerar i dag sin delårsrapport för perioden 1 januari-30 september 2021. Delårsrapporten i sin helhet finns tillgänglig som bifogad fil samt på bolagets hemsida, lipigon.se. Nedan följer en sammanfattning.

2021-11-04

Lipigon Pharmaceuticals AB ("Lipigon"), som utvecklar läkemedel mot sjukdomar orsakade av störningar i kroppens förmåga att hantera fetter, tillkännager i dag att bolaget ingått partnerskap med 5Prime Sciences ("5Prime"). Samarbetet syftar till att accelerera utvecklingsarbetet inför de kliniska prövningarna med huvudkandidaten Lipisense. Genom att använda avancerade genetiska verktyg och storskaliga samlingar av patientkohorter med miljarder datapunkter kommer 5Prime bland annat att undersöka vilka patientgrupper som kommer att dra mest nytta av en hämning av målproteinet ANGPTL4. Partnerskapet innebär att 5Prime blir Lipigons inhouse-team för humangenetik.

2021-11-04

This is an English translation of the Swedish original. In case of discrepancies, the Swedish original shall prevail.

Lipigon Pharmaceuticals AB ("Lipigon"), developer of therapeutics for lipid-related diseases, today announced a partnership with 5Prime Sciences ("5Prime") to accelerate the development of the lipid-lowering drug candidate Lipisense for upcoming clinical trials. By utilizing advanced genetic tools and large-scale collections of patient cohorts, providing billions of data points, 5Prime will, among other things, investigate which patient groups will benefit the most from ANGPTL4 inhibition. By partnering, 5Prime will become Lipigon's in-house human genetics team.

2021-10-11

I en intervju i samband med Lipigons presentation på Umeå på börsen berättar vd Stefan K. Nilsson om de senaste studieresultaten i huvudprojektet Lipisense, betydelsen av tidiga effektmått och de speciella egenskaperna med RNA-läkemedel.

2021-09-29

Umeåbaserade Lipigon Pharmaceuticals AB ("Lipigon") deltar i dag på eventet Umeå på börsen. Vd Stefan K. Nilsson berättar om utvecklingen av nya läkemedel mot sjukdomar orsakade av rubbningar i kroppens hantering av fetter, så kallade lipidrelaterade sjukdomar.

2021-09-27

Umeåbaserade Lipigon Pharmaceuticals AB ("Lipigon") kommer att delta på eventet Umeå på börsen onsdagen den 29 september. Vd Stefan K. Nilsson berättar om utvecklingen av nya läkemedel mot sjukdomar orsakade av rubbningar i kroppens hantering av fetter, så kallade lipidrelaterade sjukdomar.

2021-09-23

Lipigon Pharmaceuticals AB ("Lipigon"), som utvecklar nya behandlingar mot sjukdomar orsakade av rubbningar i kroppens hantering av fetter, så kallade lipidrelaterade sjukdomar, presenterade i går läkemedelskandidaten Lipisense vid industrikonferensen TIDES USA i Boston. Konferensen är känd som den främsta inom läkemedelsfälten oligonukleotider, peptider, mRNA och geneditering.

2021-09-14

Lipigon följer tidsplanen inför kommande kliniska studier med den första säkerhetsstudien nu avklarad. Analysguiden är positiva i en uppdaterad analys av bolaget och ser ett motiverat värde om 16-17 kronor per aktie.

2021-09-13

Umeåbaserade Lipigon Pharmaceuticals AB ("Lipigon") kommer att delta på eventet Umeå på börsen onsdagen den 29 september. Vd Stefan K. Nilsson berättar om utvecklingen av nya läkemedel mot sjukdomar orsakade av rubbningar i kroppens hantering av fetter, så kallade lipidrelaterade sjukdomar.

2021-09-10
Regulatorisk

Lipigon Pharmaceuticals AB ("Lipigon"), som utvecklar nya behandlingar mot förhöjda blodfetter, så kallade lipidrelaterade sjukdomar, rapporterar i dag att man slutfört den första av tre prekliniska säkerhetsstudier för läkemedelskandidaten Lipisense. Studien som i första hand är förberedande inför kommande, längre studier visade att Lipisense kan ges i höga doser utan att oönskade biverkningar observerades. Utöver detta visade studien att Lipisense effektivt sänkte nivåerna av blodfettet triglycerid.

2021-09-10
Regulatorisk

This is an English translation of the Swedish original. In case of discrepancies, the Swedish original shall prevail.

Lipigon Pharmaceuticals AB ("Lipigon"), a biotech company developing therapeutics for lipid-related diseases, today announced the completion of the first of three preclinical safety studies for the drug candidate Lipisense. The study, which is primarily preparatory for future, longer studies, showed that Lipisense can be given in high doses with no undesirable side effects observed. In addition, the study showed that Lipisense effectively lowered blood triglyceride levels.

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