Pressmeddelanden

Lipigon and HitGen announce achievement of an important milestone in dyslipidemia project

This is an English translation of the Swedish original. In case of discrepancies, the Swedish original shall prevail.

Lipigon Pharmaceuticals AB ("Lipigon") and HitGen Inc. ("HitGen") today announced that they have identified novel small molecules that could be starting points for developing drugs targeting dyslipidemia and cardiovascular disease.

Lipigon Pharmaceuticals AB ("Lipigon") and HitGen Inc. ("HitGen") today announced that they have identified novel small molecules that could be starting points for developing drugs targeting dyslipidemia and cardiovascular disease.

The compounds were identified using HitGen's technology platform within the framework of the companies' collaborative project on dyslipidemia. Compared to traditional high-throughput screening, HitGen's DEL technology enables the screening of thousand-fold more compounds.

The small molecules activate the enzyme lipoprotein lipase ("LPL") which plays a critical role in breaking down fat in the blood. LPL is a well-validated target for lipid disorders where Lipigon has more than 50 years of research experience. It is believed that increasing LPL activity lowers triglyceride levels, increases HDL; "the good cholesterol" and reduces the risk of cardiovascular disease and type 2 diabetes.

The small molecule LPL activator program is intended for the development of a convenient, oral medicine. There are currently no LPL activators available to patients or in development.

The identified LPL binders could be the starting point for developing a drug for dyslipidemia (lipid disorders) that remains after standard treatments with, for example, LDL cholesterol-lowering statins. Dyslipidemia is a major contributing risk factor to cardiovascular disease which is the most common cause of death in the world.

Stefan K. Nilsson, CEO and co-founder of Lipigon, comments:

"This is a major milestone in our collaboration with HitGen. After a successful screening, we have now identified chemical starting points suitable for further development. Whilst LPL has been a well-validated target for several decades it has been a hugely challenging target to activate with small molecules. It is an impressive accomplishment by our combined research team to have discovered compounds for this difficult target LPL. Being the origin of Lipigon, this project is special to all of us. Today is a day of pride."

Dr. Jin Li, Chairman of the Board and Chief Executive Officer of HitGen Inc., comments:

"I am very pleased to see our collaboration with Lipigon reach a major milestone in this very important therapeutic area. The successful identification of these compounds has further demonstrated the effectiveness and efficiency of our DEL platform to discover novel small molecules against a variety of targets. We look forward to seeing the further progress made by Lipigon. Besides, we also expect more opportunities of collaboration to empower drug discovery in more therapeutic areas."

For more information, please contact:
Stefan K. Nilsson, CEO, Lipigon
Email: stefan@lipigon.se
Phone: +46 705 78 17 68

This is information that Lipigon Pharmaceuticals AB (publ) is obliged to make public pursuant to the EU Market Abuse Regulation. The information was submitted for publication, through the agency of the contact persons set out above, at 08:30 am CET, on 21 March 2022.

About Lipigon

Lipigon develops novel therapeutics for patients with lipid metabolism disorders. The company is based on over 50 years of lipid research at Umeå University, Sweden. Lipigon's initial focus is on orphan drugs and niche indications, but in the long term, the company will have the opportunity to target broader indications in the area, such as diabetes and cardiovascular disease. Lipigon's pipeline includes four active projects: the RNA-drug Lipisense for treatment of hypertriglyceridemia; an RNA-drug for treatment of acute respiratory distress syndrome; a gene therapy treatment for the rare disease lipodystrophy, together with Combigene AB (publ); and a small molecule program for the treatment of dyslipidemia in collaboration with HitGen (Inc).

The company's share (LPGO) is traded on the Nasdaq First North Growth Market. Certified Adviser is G&W Fondkommission, email: ca@gwkapital.se, phone: +46 8 503 000 50.

About HitGen Inc.

HitGen Inc. is a biotech company headquartered in Chengdu, China, with subsidiaries in Cambridge, UK and Houston, USA. It became a publicly listed company in Shanghai Stock Exchange in April 2020 (ticker code 688222.SH). HitGen has established a drug discovery research platform for small molecules and nucleic acid drug centered on the design, synthesis and screening of DNA encoded chemical libraries (DELs), fragment-based drug discovery (FBDD) and structure-based drug design (SBDD) technologies. HitGen's DELs currently contains more than 1 trillion novel, diverse, drug-like small molecules and macrocyclic compounds. These compounds are members of DELs synthesized from many thousands of distinct chemical scaffolds, designed with tractable chemistry, and have yielded proven results for the discovery of small molecule leads against precedented and unprecedented classes of biological targets.

For more information, please call +86-28-85197385, +1-508-840-9646 or visit www.hitgen.com.
For media inquiries: media@hitgen.com
For investor inquiries: investors@hitgen.com
For business development: bd@hitgen.com

2023-05-25
Regulatorisk

I dag, den 25 maj 2023, hölls årsstämma i Lipigon Pharmaceuticals AB. Nedan följer en sammanfattning av de beslut som fattades. Samtliga beslut fattades med erforderlig majoritet.

2023-05-25
Regulatorisk

Lipigon Pharmaceuticals AB ("Lipigon") publicerar i dag sin delårsrapport för perioden 1 januari-31 mars 2023. Delårsrapporten i sin helhet finns tillgänglig som bifogad fil samt på bolagets hemsida, www.lipigon.se. Nedan följer en kort sammanfattning.

2023-05-17

Lipigon Pharmaceuticals AB ("Lipigon"), som utvecklar läkemedel mot sjukdomar orsakade av rubbningar i kroppens hantering av fetter, meddelar i dag att den sista patienten har avslutat behandlingen i den kliniska fas I-studien av läkemedelskandidaten Lipisense. Studien syftade främst till att bedöma säkerheten och tolerabiliteten av Lipisense vid behandling av svår hypertriglyceridemi.

2023-05-17

Lipigon Pharmaceuticals AB ("Lipigon"), a clinical-stage pharmaceutical company focused on developing novel therapeutics for lipid-related diseases, today announced that the last patient had completed the study protocol of its Phase I clinical trial for drug candidate Lipisense. The trial primarily aimed to assess the safety and tolerability of Lipisense in the treatment of severe hypertriglyceridemia.

2023-05-17

Den 24 maj kl. 11.05 presenterar Lipigons vd Stefan K. Nilsson bolagets senaste utveckling på Redeye.

2023-05-16
Regulatorisk

Lipigon Pharmaceuticals AB ("Lipigon") som utvecklar läkemedel mot sjukdomar orsakade av rubbningar i kroppens hantering av fetter, meddelar i dag att de har valt kontraktsforskningsorganisation (CRO) för planering och utformning av den kliniska fas II-studien med Lipisense. Studien syftar till att studera säkerhet och behandlingseffekt hos patienter med kraftigt förhöjda nivåer av blodfettet triglycerid.

2023-05-11
Regulatorisk

Företrädesemissionen i Lipigon Pharmaceuticals AB ("Lipigon" eller "Bolaget") som avslutades den 24 april 2023 är nu registrerad hos Bolagsverket och betalda tecknade units (BTU) kommer att ersättas med aktier och teckningsoptioner serie TO2 och TO3. Sista dag för handel med BTU är den 15 maj 2023 och stoppdag hos Euroclear är den 17 maj 2023.

2023-05-04
Regulatorisk

Styrelsen i Lipigon Pharmaceuticals AB (''Lipigon") har i dag beslutat om riktad emission av 154 971 units till vissa garanter ("Ersättningsemissionen") i den företrädesemission av units, som godkändes av bolagsstämman den 30 mars 2023 ("Företrädesemissionen"). Dessa garanter har valt att erhålla garantiersättning i form av units i Lipigon i stället för kontant betalning. Teckningskursen i Ersättningsemissionen motsvarar teckningskursen i Företrädesemissionen, dvs. 3,50 SEK per unit.

2023-05-02
Regulatorisk

Lipigon Pharmaceuticals AB ("Lipigon") tillkännager i dag utnämningen av Hugo Petit som CFO. Hugo Petit har lång och bred erfarenhet av CFO-befattningar inom life science-sektorn.

2023-04-27
Regulatorisk

Lipigon Pharmaceuticals AB:s årsredovisning för 2022 har offentliggjorts och finns tillgänglig på bolagets webbplats. Den summerar ett spännande år präglat av många positiva händelser. Bland annat har läkemedelskandidaten Lipisense gått in i kliniska prövningar och erhållit positiva säkerhetsresultat från fas I-studierna.

2023-04-26
Regulatorisk

Lipigon Pharmaceuticals AB (''Lipigon" eller ''Bolaget'') offentliggör idag utfallet i Bolagets företrädesemission av units om cirka 35,4 MSEK som avslutades den 24 april 2023 ("Företrädesemissionen"). 4 279 341 units tecknades med och utan stöd av uniträtter, vilket motsvarar cirka 42,3 procent av Företrädesemissionen. 4 104 434 units, vilket motsvarar cirka 40,5 procent, tecknades av emissionsgaranter. Företrädesemissionen tecknades därmed till cirka 82,8 procent och Lipigon tillförs därigenom cirka 29,3 MSEK före emissionskostnader.

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