Pressmeddelanden

Lipigon expands collaboration with HitGen to develop a second novel drug for lipid disorders

Lipigon Pharmaceuticals AB ("Lipigon"), developer of therapeutics for lipid-related diseases, today announced that the company has expanded its agreement with the Shanghai STAR listed company HitGen Inc. ("HitGen") to include a second novel target protein. With joint efforts, the aim is to develop a treatment for cardiometabolic disease.

Lipigon and HitGen have been collaborating on developing molecules enhancing the enzyme lipoprotein lipase ("LPL") activity since May 2020, with the aim to develop a novel drug for lipid disorders. Now the time is right to expand the collaboration by selecting a second, yet undisclosed, target protein.

By using HitGen's proprietary DEL screening platform, the parties will identify novel small molecules and jointly develop a candidate drug. HitGen's DEL technology enables screening of thousands of times more compounds than with traditional high-throughput screening. Lipigon will be responsible for clinical development and out-licensing of commercialization rights of the drug candidates. HitGen is entitled to a starting fee and revenue sharing for any candidate resulting from the collaboration.

"We are deeply impressed by the HitGen team's professionalism and hard work in the pre-screening activities of target protein 1 - LPL. We are therefore pleased to expand our collaboration to include a second target," said Dr. Stefan K. Nilsson, CEO of Lipigon. "Target protein 2 is just as exciting as LPL and has a similarly strong genetic and clinical validation. HitGen's world-leading screening platform will give us a good shot at finding relevant starting points for drug development."

"HitGen is determined to help biology expert companies, such as Lipigon, finding new small-molecule leads where traditional screening has not been successful. We have a good track record of succeeding with difficult target proteins and with the input of Lipigon we hope to bring good lead candidates to the table," said Dr. Jin Li, Chairman of the Board and Chief Executive Officer of HitGen.

Umeå March 10, 2021

For more information, please contact:
Stefan K. Nilsson, CEO, Lipigon
Email: stefan@lipigon.se 
Phone: +46 705 78 17 68

This is information that Lipigon Pharmaceuticals AB (publ) is obliged to make public pursuant to the EU Market Abuse Regulation. The information was submitted for publication, through the agency of the contact person set out above, at 1.00 pm CET, on 10 March 2021.

This is an English translation of the Swedish original. In case of discrepancies, the Swedish original shall prevail.

About Lipigon
Lipigon develops novel therapeutics for patients with lipid metabolism disorders. The company is based on over 50 years of lipid research at Umeå University, Sweden. Lipigon's initial focus is on orphan drugs and niche indications, but in the long term, the company will have the opportunity to target broader indications in the area, such as diabetes and cardiovascular disease. Lipigon's pipeline includes four active projects: the RNA-drug Lipisense, for treatment of hypertriglyceridemia; an RNA-drug for treatment of acute respiratory distress syndrome; a gene therapy treatment for the rare disease lipodystrophy, together with Combigene AB (publ); and a small molecule program for treatment of dyslipidemia in collaboration with HitGen (Inc).

The company's share (LPGO) is traded on the Nasdaq First North Growth Market. Certified Adviser is G&W Fondkommission, email: ca@gwkapital.se, phone: +46 8 503 000 50.

About HitGen Inc.
HitGen Inc. is a rapidly developing biotech company headquartered in Chengdu, China, with subsidiaries in Cambridge, UK and Houston, USA. It became a publicly listed company in Shanghai Stock Exchange in April 2020 (ticker code 688222.SH). HitGen has established an industry-leading platform for early-stage drug discovery research, based on DNA encoded chemical libraries (DELs).

HitGen is collaborating with pharmaceutical, biotech and chemical companies, foundations and research institutes in North America, Europe, Asia, Africa, and Australia to enable the discovery and development of novel medicines and agrochemicals.

For more information, please call +86-28-85197385, +1-508-840-9646 or visit www.hitgen.com.

For media inquiries: media@hitgen.com 

For investor inquiries: investors@hitgen.com 

For business development: bd@hitgen.com 

2021-10-11

I en intervju i samband med Lipigons presentation på Umeå på börsen berättar vd Stefan K. Nilsson om de senaste studieresultaten i huvudprojektet Lipisense, betydelsen av tidiga effektmått och de speciella egenskaperna med RNA-läkemedel.

2021-09-29

Umeåbaserade Lipigon Pharmaceuticals AB ("Lipigon") deltar i dag på eventet Umeå på börsen. Vd Stefan K. Nilsson berättar om utvecklingen av nya läkemedel mot sjukdomar orsakade av rubbningar i kroppens hantering av fetter, så kallade lipidrelaterade sjukdomar.

2021-09-27

Umeåbaserade Lipigon Pharmaceuticals AB ("Lipigon") kommer att delta på eventet Umeå på börsen onsdagen den 29 september. Vd Stefan K. Nilsson berättar om utvecklingen av nya läkemedel mot sjukdomar orsakade av rubbningar i kroppens hantering av fetter, så kallade lipidrelaterade sjukdomar.

2021-09-23

Lipigon Pharmaceuticals AB ("Lipigon"), som utvecklar nya behandlingar mot sjukdomar orsakade av rubbningar i kroppens hantering av fetter, så kallade lipidrelaterade sjukdomar, presenterade i går läkemedelskandidaten Lipisense vid industrikonferensen TIDES USA i Boston. Konferensen är känd som den främsta inom läkemedelsfälten oligonukleotider, peptider, mRNA och geneditering.

2021-09-14

Lipigon följer tidsplanen inför kommande kliniska studier med den första säkerhetsstudien nu avklarad. Analysguiden är positiva i en uppdaterad analys av bolaget och ser ett motiverat värde om 16-17 kronor per aktie.

2021-09-13

Umeåbaserade Lipigon Pharmaceuticals AB ("Lipigon") kommer att delta på eventet Umeå på börsen onsdagen den 29 september. Vd Stefan K. Nilsson berättar om utvecklingen av nya läkemedel mot sjukdomar orsakade av rubbningar i kroppens hantering av fetter, så kallade lipidrelaterade sjukdomar.

2021-09-10
Regulatorisk

Lipigon Pharmaceuticals AB ("Lipigon"), som utvecklar nya behandlingar mot förhöjda blodfetter, så kallade lipidrelaterade sjukdomar, rapporterar i dag att man slutfört den första av tre prekliniska säkerhetsstudier för läkemedelskandidaten Lipisense. Studien som i första hand är förberedande inför kommande, längre studier visade att Lipisense kan ges i höga doser utan att oönskade biverkningar observerades. Utöver detta visade studien att Lipisense effektivt sänkte nivåerna av blodfettet triglycerid.

2021-09-10
Regulatorisk

This is an English translation of the Swedish original. In case of discrepancies, the Swedish original shall prevail.

Lipigon Pharmaceuticals AB ("Lipigon"), a biotech company developing therapeutics for lipid-related diseases, today announced the completion of the first of three preclinical safety studies for the drug candidate Lipisense. The study, which is primarily preparatory for future, longer studies, showed that Lipisense can be given in high doses with no undesirable side effects observed. In addition, the study showed that Lipisense effectively lowered blood triglyceride levels.

2021-09-08

Data från prekliniska studier utförda av professor Sander Kersten, vetenskaplig rådgivare till Lipigon Pharmaceuticals AB ("Lipigon"), indikerar att Lipigons huvudkandidat Lipisense är både säker och effektiv mot förhöjda blodfetter i försöksdjur. Professor Sander Kersten presenterade data på European Lipoprotein Club (ELC), ett av världens ledande forskarmöten inom området blodfetter, i Tutzing, Tyskland.

2021-09-02

Lipigon Pharmaceuticals är experter på blodfetter och utvecklar läkemedel för behandling av höga blodfetter. Bolaget driver fyra utvecklingsprojekt och arbetar både med RNA-läkemedel, genterapi och småmolekyler. "Vi väljer den metod eller teknologi som passar våra målproteiner bäst och kan därmed tänka och jobba väldigt fritt", berättar vd Stefan K. Nilsson. Läs hela intervjun här.

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